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Study Demonstrates That Cannabis Is An ‘Exit Drug’ Not A ‘Gateway Drug’

Arguably the most popular talking point among cannabis opponents is the false claim that ‘cannabis is a gateway drug.’ Cannabis opponents have gone to great lengths and dedicated enormous resources to spreading that false narrative.

The fact of the matter is that cannabis is not a gateway drug. Numerous studies have found that people often use other substances before they ever use cannabis including alcohol, tobacco, pharmaceuticals, and the misuse of everyday household items such as aerosols.

Furthermore, a vast majority of cannabis consumers do not go on to use more harmful substances. All someone has to do is look at the cannabis consumption rate in a given jurisdiction and compare it to the usage rates for more harmful substances and it’s blatantly obvious that cannabis is not a gateway drug.

A growing body of evidence is actually finding that cannabis is an ‘exit drug,’ meaning that consumers of more harmful substances are successfully incorporating cannabis into their harm-reduction strategies. Below is information about a recent study in Canada that highlights the research surrounding this topic via a news release from NORML:

Vancouver, Canada: Polydrug users frequently engage in the use of cannabis in order to decrease their consumption of stimulants like crystal methamphetamine, according to data published in the journal Addictive Behaviors.

Canadian researchers surveyed a cohort of 297 polydrug users who engaged in the use of cannabis and unregulated stimulants. Nearly half (45 percent) of those surveyed reported having consumed cannabis to manage their stimulant cravings. Of those, 78 percent “reported decreasing their stimulant use during periods of cannabis use.”

Investigators reported that cannabis was frequently associated with reductions among those who used methamphetamine. They reported no decrease in use among those who engaged in the daily use of cocaine.

Prior studies have reported inconsistent findings with respect to the use of cannabinoids as a substitute for cocaine. For example, a pair of longitudinal trials from Brazil and Canada reported that the use of cannabis is associated with the decreased use of crack cocaine in dependent subjects. By contrast, a 2021 study reported that the daily administration of CBD failed to reduce cocaine cravings any better than placebo in subjects with a history of moderate to severe cocaine abuse.

The study’s authors concluded: “These findings indicate that cannabis use to manage stimulant cravings is a common harm reduction strategy and suggest that this may be an effective strategy to reduce stimulant use among some PWUD [people who use unregulated drugs]. … In the absence of established pharmacotherapies for the treatment of stimulant use disorders, further investigation of the harm reduction and therapeutic applications of cannabis use is warranted to address the harms of stimulant use.”
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Numerous other studies have previously reported that cannabis consumers often substitute it in place of other substances, including alcohol, tobacco, and prescription opioids.

Full text of the study, “Cannabis use to manage stimulant cravings among people who use unregulated drugs,” appears in Addictive Behaviors.

CBDV Moderates Fragile X Syndrome Progression According To French Study

The cannabis plant is made up of dozens of cannabinoids, with two of the most well-known examples being tetrahydrocannabinol (THC) and cannabidiol (CBD). Both cannabinoids are the focus of a growing body of peer-reviewed research, and rightfully so.

However, in recent years other lesser-known cannabinoids have risen in popularity within the international research community, including cannabidivarin (CBDV). CBDV, much like CBD, does not induce intoxication.

Researchers in France recently examined CBDV and its potential as a treatment for Fragile X Syndrome. Below is more information about the study via a news release from NORML:

Bordeaux, France: The administration of the cannabinoid cannabidivarin (CBDV) moderates the progression of Fragile X syndrome (FXS), according to preclinical data published in the journal Cells.

An international team of researchers from France, Italy, the United Kingdom, and the United States assessed the efficacy of CBDV treatment in a mouse model of Fragile X syndrome. FXS is a genetic disorder resulting in developmental delays, learning disabilities, and behavioral problems, such as aggression and attention deficits.

Investigators reported that CBDV administration during adolescence prevented cognitive and behavioral changes in a manner similar to other pharmacological treatments. By contrast, CBDV’s effects were “marginal” when the compound was administered during adulthood.

They determined: “Overall, these data demonstrate that CBDV, when administered chronically and starting at juvenile age, holds a solid therapeutic potential for FXS as it prevented the most relevant behavioral alterations shown by … mice. Early timing and chronic duration of treatment appear as critical determinants to ensure the beneficial effects of CBDV.”

The study’s authors concluded, “These results thus encourage future clinical studies using phytocannabinoids for treating not only FXS but also other neurodevelopmental disorders.”

Parents and caregivers of children with FXS patients report using CBD for symptom management. The administration of a transdermal gel containing CBD has been shown to be safe and effective in FSX patients in randomized, placebo-controlled clinical trials.

Full text of the study, “Early administration of the phytocannabinoid cannabidivarin prevents the neurobehavioral abnormalities associated with the Fmr1-KO mouse model of Fragile X syndrome,” appears in Cells.

Attend The 2023 Cultiva Hanfexpo In Vienna October 6th-8th

An amazing opportunity is coming up this week in Vienna, Austria with the start of the Cultiva Hanfexpo on October 6th. The three-day hemp expo and festival is the largest in Austria and will take place at the Marx Halle.

At the expo, visitors will find all of the information that they need to know about the hemp plant and the products derived from it. National and international exhibitors will display their products and contribute to a unique exhibition experience. Below is more information about the event:

15 YEARS OF CULTIVA

Over the last 15 years, Cultiva has brought together people from all over the world to discuss the uses of hemp and develop new ideas. This event is important to unite and support the Austrian hemp industry. It all started in 2008 at the Pyramide in Vösendorf.

“They were expecting big tables with Indian sheets. Then when the trucks came and one-story platforms were set up, it caused a big surprise moment for the management of the event venue,” founder Harald Schubert recalls of the beginnings of Cultiva. At first, he says, there were doubts about the exhibition, because “they didn’t know what to expect”. But these hesitations quickly disappeared.

Around 5,000 visitors came to the first hemp exhibition. The aim was to provide a platform for the hemp plant and its use, the industry and its development, as well as the many socio-political issues associated with it. This has not changed over the years, but the size of the exhibition has.

“We attracted higher-value branches because of the higher purchasing power in Austria, and that set us apart from other hemp exhibitions in Europe,” says founder Schubert.

Even after 15 years, the glassblowing show is still a fixed part of the fair. Other highlights of the past 15 years of Cultiva included visits from Christian Rätsch, Jorge Cervantes and “Mr. Nice” Howard Marks. And, of course, the many performances by bands and DJs. “It’s the most iconic expo,” Schubert says.

EXPERIENCE THE WONDER OF HEMP

The WORLD OF HEMP represents one of the most extensive areas at the exhibition. On 400 sqm all information about cannabis is shown in an exciting and informative way. This interactive area educates visitors about the cannabis plant and helps them to get to know it better. Different sections can be explored with the help of a guiding system.

Whether learning, tasting, participating or trying out: The WORLD OF HEMP serves all the senses and invites you to further education.

GLASSBLOWING-SHOW – TORCHLAND GLASS CIRCUS BY THCBD AUSTRIA

Another highlight at CULTIVA HANFEXPO is the glassblowing show Torchland Glas Circus by THCBD Austria. During the live show, professionals such as Orglasmus, Nathan Belmont, Sibelle Yuksek, Fedex Glass and Tibor Toth will demonstrate the art of glassblowing and engraving. If interested, the products can be purchased afterwards.

CULTSOUND FESTIVAL

The CULTSOUND Music Festival is a new star in the sky of the Viennese event calendar. From electro to reggae sounds – the three-day music festival with its extraordinary location offers a special experience. The venue – the headquarters of the artist collective R:JOURNEY – provides the ideal setting. Acts such as the band Mary Jane Soundgarden, Matej, Sun State of Mind
will ensure a hot atmosphere and danceable sounds, and Sunday will be hosted by WNMR – If Not With Rap. Food trucks with a variety of dishes from meat or vegan to sweet and a bar provides for the physical well-being.

CULTIVA CONGRESS

The CULTIVA HANFEXPO CONGRESS offers an insight into the topics of law, politics, medicine as well as culture and innovation. National and international experts from different fields share their knowledge and clarify important questions about cannabis in the form of lectures and panel discussions. The focus will be on both the current regulations on the subject of cannabis and
the future of the industry. What changes can we expect in the hemp industry? What could the situation look like in five years? These and other questions will be answered during the congress.

BUSINESS BRUNCH

On Friday and Saturday all business visitors and exhibitors are invited to aur Networking Brunch in the Business lounge at the exhibition.
• Friday, 06.10.2023 09:00 – 11:00 a.m.
• Saturday, 07.10.2023 09:00 – 11:00 a.m.

Find out more information at: https://www.cultiva.at/lang%3Den/index.htm

French Medical Cannabis Legalization Is Not Expected In 2024

France’s government is expected to refrain from recommending national medical cannabis legalization after the European nation’s medical cannabis experiment is over.

In March 2021, France launched a limited medical cannabis experiment involving between 2,000 and 3,000 suffering patients with the goal of gaining insight to possibly craft national medical cannabis policies and regulations. Initially slated for a two-year period, France’s medical cannabis experiment was eventually granted a one-year extension and is set to end in 2024.

According to domestic reporting, the 2024 Social Security Financing Bill (PLFSS) will not include provisions to legalize medical cannabis nationwide due to a lack of support by the Macron administration.

The French medical cannabis experiment received initial approval from the federal Senate back in 2019, however, the launch of the trial was delayed until the spring of 2021 due to various reasons. Cannabis producer LaFleur was eventually selected as the cultivator for the program and has supplied participating patients since the launch of the experiment.

Limited cannabis access is not a new public policy concept in Europe, with limited adult use cannabis commerce now permitted in parts of Switzerland, and soon, the Netherlands. Germany is another jurisdiction that is working towards launching adult-use pilot programs.

France is somewhat rare in that most European nations now permit medical cannabis access. France, on the other hand, has historically been much more hesitant to reform its medical cannabis policies.

If the French government does not adopt national medical cannabis reform at the conclusion of the experiment, and the pilot program does not receive another extension, medical cannabis patients will have no safe access to their medications. Instead, they will be forced to either go without medical cannabis or obtain their medical cannabis from unregulated sources.

CBD products containing less than 0.3% THC are legal in France, however, many suffering cannabis patients require treatment regimens involving products that have higher levels of THC.

According to data analyzed by the French Observatory of Drugs and Addictive Tendencies, roughly 10.6% of France’s adult population has consumed cannabis within the last year, and 47.3% have reported using cannabis at least once in their lifetimes.

Survey Finds Athletes Report Using Cannabis Products To Promote Exercise Recovery

For many years athletes were discouraged from consuming cannabis at all costs. They were often told by their coaches and trainers that cannabis was bad for them, that it was a ‘gateway drug,’ and that it would ruin their athletic aspirations.

These days many athletes openly admit to being cannabis consumers, including elite athletes in professional sports leagues. Those athletes, as well as amateur athletes who consume cannabis, are proving that cannabis can absolutely be a part of an active lifestyle.

A recent study was conducted in the United States that surveyed athletes to gain insight into their cannabis consumption habits. Below is more information about it via a news release from NORML:

Kent, OH: Those who engage in regular exercise frequently report consuming cannabis products to assist in recovering from physical activity, according to data published in the Journal of Cannabis Research.

Researchers affiliated with Kent State University in Ohio surveyed over 100 subjects who reported using cannabis and regularly engaging in aerobic and/or resistance exercise.

Investigators summarized their findings as follows: “Twenty-two participants (20 percent) reported using CBD for recovery from aerobic exercise and 25 participants (23 percent) reported CBD use to recover from resistance exercise. Sixty-eight participants (61 percent) reported using THC after aerobic exercise for recovery. Similarly, 67 participants (60 percent) reported using THC after resistance exercise for recovery. When participants were asked, ‘Do you feel that cannabis in the form of CBD aids in your recovery?’ 93 percent stated ‘yes’ while seven percent stated, ‘I’m not sure.’ When asked, ‘Do you feel that THC aids in your recovery?’, 87 percent of participants stated, ‘yes’ while 13 percent stated, ‘I’m not sure’. No participant answered, ‘no’, for either of these questions. All of the participants felt that use of cannabis was low risk regarding health outcomes.”

The authors concluded: “The present study demonstrated that in addition to more traditional recovery methods, cannabis is used as an ergogenic recovery aid by individuals that exercise regularly. … More data are necessary to understand the role of cannabis in exercise recovery as well as perceived ergogenic benefits of cannabis by individuals who both regularly participate in exercise and habitually use cannabis.”

Another study published in the same journal earlier this year reported that the twice-daily use of topical CBD alleviates chronic pain in former elite-level (professional) athletes.

Several other studies have found that cannabis use is associated with increased exercise frequency, including among older adults. Yet another study, published in July, found that subjects reported “a more positive exercise experience” when they ran immediately after having used cannabis compared to when they did not.

Full text of the study, “Cannabis use for exercise recovery in trained individuals: A survey study,” appears in the Journal of Cannabis Research.

Accusations Of Inflated THC Potency Surface In Canada

A coalition of cannabis producers and testing laboratories in Canada are alleging that some entities are inflating their cannabis product THC potency levels, sometimes as much as twenty percent.

“There are cannabis companies in the top 10 that are absolutely inflating their flower values,” said Borna Zlamalik, senior vice-president of innovation and research and development at Moncton-based producer OrganiGram Holdings Inc. The comments were first reported by Globe and Mail. “I think there are some companies that have maliciously narrowed down their sample procedures to get the best flower.”

Allegations of THC inflation are not new in the cannabis industry. Part of the problem is on the producer/laboratory/retailer side of the equation, however, there’s also some blame on the consumer side as well.

It’s well known in the cannabis world that many consumers, for better or worse, rely solely on THC percentage when making their purchasing decisions. That ‘THC shopping’ phenomenon compounds the problem as entities strive to get the highest THC percentage on their flower products regardless of whether quality is being boosted or not.

The latest allegations being hurled in Canada highlight the growing need to overhaul how cannabis is organized. Indica, sativa, and THC percentages – they are all archaic ways of categorizing cannabis products.

Instead, true science should drive how cannabis products are categorized, led largely by ‘terpene profiles.’ Terpenes are found in all cannabis flower, and it’s what gives cannabis its smell. The cannabis plant contains dozens of terpenes in different ratios, often referred to as terpene profiles.

Knowing a harvest’s terpene profile is a much better indicator of what effects and wellness benefits a consumer or patient can expect compared to one lab’s testing results of a very small sample of the harvest.

Different terpenes are associated with different effects, and while it’s a more cumbersome form of categorization compared to a simple indica/sativa model, it’s far more insightful and will undoubtedly serve as the future of how cannabis is viewed by dispensary and cannabis club customers.

Slowing Down Legalization In Germany Is The Wrong Move

A coalition of SPD ministers from Hamburg, Thuringia, and Lower Saxony are trying to slow down cannabis policy modernization efforts in Germany. Germany’s current legalization effort was historically led by Germany’s Health Minister Karl Lauterbach (SPD). If the coalition of SPD state ministers have their way, Minister Lauterbach’s bill will never become law.

What is currently being proposed is a multi-phase plan to modernize Germany’s adult-use cannabis policies. The first phase, which was approved this year by Germany’s federal cabinet, would legalize the personal cultivation, possession, and use of cannabis.

Additionally, the first phase would eventually permit noncommercial cannabis clubs to operate. The clubs would be subject to a host of regulations, including caps on the number of members they can have. Individual consumers would also be restricted to only possessing one membership at a time.

While Germany’s federal cabinet approved the first phase measure, it is now being considered by members of the Bundestag and it’s very likely that provisions of the bill will evolve, and not in a manner that the coalition of SPD state ministers are hoping for.

Unlike the SPD state ministers, who feel that the current measure being considered is too liberal, many members of the Bundestag have expressed publicly that they feel the current measure is too restrictive.

The second phase of legalization according to Minister Lauterbach’s proposal would involve permitting regional adult-use cannabis commerce pilot programs, similar to what is in operation in Switzerland and being considered in the Netherlands. Although, Germany’s pilot programs are expected to be conducted on a larger scale than compared to its European counterparts’ programs.

A cannabis pilot program, in theory, provides national lawmakers the opportunity to collect data at a local level in order to be better suited to craft national cannabis laws and regulations. Full national sales are not within the scope of the current legalization effort in Germany, although there’s a lot of the process left to be completed and anything is possible.

Germany’s Health Minister participated in ongoing discussions with the European Union regarding cannabis policy, and Minister Lauterbach indicated that national sales would run afoul of EU agreements. Malta and Luxembourg have passed national legalization measures, however, they do not include provisions for national sales.

Slowing down the process in Germany is unacceptable. If anything, it needs to be sped up. Cannabis prohibition is a failed public policy, and regulation is a more sensible approach. Canada is proving that right now, and it would be wise for Germany and every other country to modernize their own cannabis policies.

Cannabis Seminary For Doctors And Nurses To Be Held At University Of Ljubljana

Check out the upcoming event at the University of Ljubljana titled ‘Hemp and its Active Ingredients in Healthcare III’ on October 11th and 18th, 2023. The event is co-organized by the Research Nature Institute and is the third education seminary of a series involving doctors and nurses from the faculty at the University of Ljubljana.

The first day of lectures will discuss examples of good practices for nurses and doctors in Slovenia and abroad. Topics will include dosage recommendations, destigmatizing cannabis, and the treatment of neurodevelopmental syndromes.

The second day of presentations will explore potential issues and harm-reduction techniques for consuming cannabis for medical purposes. Attendees will hear for the first time how successful the clinical treatment of multiple sclerosis, Parkinson’s, and Alzheimer’s disease is in Uruguay. Below is the event’s program:

Wednesday, 11/10/2023 – hybrid 

16:00 – 16:05 Welcome address
16:05 – 16:45 Education of health workers on the use of cannabis and cannabinoids for medical purposes: literature review
Jasna Kovač, mag. dr. care, Pediatric Clinic UKC, MEDCA
Tatjana Lončar, B.Sc. med sestra Gynecology Clinic UKC, MEDCA
16:45 – 17:25 US Nurses Journey to Reduce the Stigma of Medical Cannabis ( Maureen Smyth, BSN RN, Certified Cannabis Nurse educator (USA) – ZOOM)
17:25 – 17:35 Break
17 :35 – 18:15 Treatment of neurodevelopmental syndromes with cannabidiol and medical cannabis (Prof. Dr. David Neubauer, MD)
18:15 – 19:00 Dosing – Developing a Cannabis Dose-Effect Hypothesis / “The Dosing Project – developing a Cannabis Dose-Effect Hypothesis« (dr. Jean Talleyrand, MD (USA) – ZOOM))

Research and findings in medicine
Wednesday, 18.10.2023 – hybrid

16:00 – 16:40    Kanabinoidi pri zdravljenju raka, primer glioblastoma (prof. dr. Tamara Lah Turnšek (NIB))
16:40 – 17:20    Problematic Cannabis Use of Medicinal Cannabis (dr. Ilya Reznik, MD – ZOOM)
17:20 – 17:30   Odmor
17:30 -18:10    Can Cannabis treat endometriosis (dr. Lumir Hanuš – ZOOM)
18:10 – 18:50  Therapeutic implications of cannabinoid actions in the brain and neurodegenerative diseases. A clinical perspective in Multiple Sclerosis, Parkinson’s disease, Alzheimer’s disease. (dr. Raquel Peyraube, MD (Urugvaj) – ZOOM)

The event will be moderated by journalist Mr. Gorazd Rečnik, who will lead the discussion and enable the lecturers and guests to ask questions online.

The seminar is intended for the general public, experts, health workers, politicians and officials, who will make future decisions in the field easier with the acquired knowledge.

Lectures will be held in Slovenian and English.

METHOD OF IMPLEMENTATION – hybrid:
– live  at the Faculty of Medicine, Zdravstvena pot 5, Ljubljana  or
– in an online environment.

CO-ORGANIZER : RN, Institute for Nature Research, Development and Quality Assurance of Natural Medicines, with which the Faculty of Health UL has been actively cooperating for many years, is a research and educational institution.

APPLICATION

REGISTRATION

30 EUR with VAT (exclusively for both days).

The content of the education is to obtain points from the ZZBNS and the Medical Chamber of Slovenia.

Participants receive certificates.

For more information about individual lectures and lecturers, write to vesna.osojnik@zf.uni-lj.si, call 01 300 11 65, or go to: https://www.zf.uni-lj.si/si/arhiv-obvestil-cvu/1295-konoplja-in-njene-ucinkovine-v-zdravstvu-iii

Changes Expected To Be Made To Thailand’s Cannabis Policy

In June 2022, Thailand’s government made a fairly substantial shift in how it approaches cannabis policy. At the time the policy change was hailed as ‘legalization,’ however, it’s worth noting that what was legalized was low-THC cannabis.

Still, it was a historic shift for a nation located in Southeast Asia where some of the harshest cannabis policies on earth are also located. Every household in the entire country became eligible to sign up to legally cultivate low-THC cannabis plants. It’s the first time in the history of the world that such a public policy was implemented at a national level.

For a time things seemed to be very exciting in Thailand. As part of the rollout of the new law, Thailand gave away over 1 million cannabis seeds directly to households that signed up to cultivate cannabis. The government even gave out low-interest loans to help aspiring cultivators get their operations started.

The Health Ministry largely led the charge for cannabis policy modernization in Thailand, however, a broad spectrum of government agencies in Thailand entered into an agreement to do their part to push Thailand’s emerging cannabis industry forward. Unfortunately, the honeymoon period appears to be over, as captured in the X post below:

A cannabis and hemp regulation bill sponsored by the Bhumjaithai Party passed its first reading in parliament in June, and ministries in Thailand are forming a committee to review the measure and will eventually provide their own recommendations.

“Whether we continue with the present draft or develop a new one, I insist there must be laws to control cannabis use,” said Public Health Minister Cholnan Srikaew according to Bangkok Post. “Using cannabis for recreational purposes must be forbidden. The improper use of cannabis will lead to dangers for users.”

The cannabis policy discussion in Thailand will now largely focus on what constitutes medical cannabis use versus ‘recreational’ use. It’s not a new discussion within the global cannabis community, as many advocates around the globe feel very passionately that all cannabis use is medical to some degree.

As with any public policy change, the devil will be in the details, and how long the process will take is anyone’s guess. Furthermore, it will be interesting to see how meaningful any changes prove to be, as enforcement could prove to be difficult after so much has transpired. It’s an interesting situation from a public policy standpoint, to say the least.