Tag: croatia

It’s fairly common for someone to feel fatigued as the day goes on, especially when it comes to suffering patients who may already struggle with fatigue due to their health condition(s). Even for non-suffering patients, the ‘two-thirty feeling’ can be real when tiredness sets in around the middle of the afternoon.

A number of products and services profess to boost energy throughout the day, with varying levels of effectiveness. Many energy-boosting products contain large amounts of added sugar and other additives that are not always healthy.

Researchers in Croatia recently conducted a clinical trial to determine if cannabidiol (CBD) can be effective at reducing daytime fatigue. Below is more information about the results of the clinical trial via a news release from NORML:

Split, Croatia: CBD administration is associated with decreased daytime fatigue and improved psychological well-being, according to randomized placebo-controlled data published in the journal Cannabis and Cannabinoid Research.

A team of Croatian researchers assessed the use of CBD versus placebo on participants’ quality of life. Subjects consumed either CBD or placebo for five-week intervals.

“Five-week administration of CBD, but not of placebo, resulted in improvement of ESS [Epworth sleepiness scale] score as well as fatigue/vitality and psychological well-being,” investigators concluded. Although subjects reported reduced incidents of daytime sleepiness, they did not similarly report improvements in their overall sleep quality.

Prior studies have reported that CBD dosing before bedtime is associated with improved sleep quality in patients with a history of sleep disturbances.

Full text of the study, “Chronic cannabidiol administration mitigates excessive daytime sleepiness and fatigue in patients with primary hypertension: insights from a randomized crossover trial,” appears in Cannabis and Cannabinoid Research.

Hypertension occurs when someone’s blood pressure is too elevated, typically above 140/90. The condition is considered severe if the pressure is above 180/120.  If left untreated, hypertension can cause serious health conditions, including heart disease and stroke.

International health experts estimate that roughly 30% of the planet’s adult human population suffers from hypertension to some degree, which works out to over one billion people globally.

Fortunately, the cannabis plant may be able to help, as evidenced by the results of a new study out of Croatia which examined the use of oral CBD and how it affects hypertension patients. Below is more information about the new study via a news release from NORML:

Split, Croatia: The oral administration of a proprietary encapsulated dose of CBD reduces ambulatory blood pressure in subjects suffering from either mild or moderate hypertension, according to placebo-controlled clinical trial data published in the journal Cannabis and Cannabinoid Research.

Researchers assessed the efficacy of CBD versus placebo in a cohort of 70 patients. Subjects received daily doses of either CBD or a placebo for five weeks. Patients consumed between 225 mgs and 450 mgs of CBD per day.

“The administration of CBD reduced average 24-hour mean, systolic, and diastolic BP [blood pressure] after 2.5 weeks,” investigators concluded. “There were no changes in liver enzymes of serious adverse events.”

Authors concluded: “The results of the present randomized, triple-blind, crossover study indicate that chronic administration of CBD [capsules] reduces ambulatory BP. … These findings should be confirmed in larger prospective cohorts to apply them into clinical practice.”

The trial’s findings are consistent with those of a 2017 British study finding that the administration of a single oral dose of 600 mgs of CBD reduced blood pressure in healthy volunteers. Another study reported that CBD dosing was associated with sustained lower levels of stress-induced high blood pressure

Israeli data has shown that the use of whole-plant cannabis also modulates blood pressure control. Authors of a 2021 study of elderly hypertension subjects determined, “Cannabis treatment for three months was associated with a reduction in systolic and diastolic blood pressure, as well as heart rate.” More recently, an analysis in the journal Nature: Scientific Reports concluded that current and lifetime cannabis use is associated with lower blood pressure levels in men and women.

Full text of the study, “Chronic effects of oral cannabidiol delivery on 24-h ambulatory blood pressure in patients with hypertension: A randomized, placebo-controlled, and cross-over study,” appears in Cannabis and Cannabinoid Research. Additional information on cannabinoids and blood pressure regulation is available from NORML’s publication, Clinical Applications for Cannabis and Cannabinoids.